A Nonthoracotomy Myocardial Infarction Model in an Ovine Using Autologous Platelets

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A Nonthoracotomy Myocardial Infarction Model in an Ovine Using Autologous Platelets

OBJECTIVE There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS Mepacrine stained autologous platelets from male sheep (n = 7) were used to create a myocardial infarction via catheter injec...

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Clinicopathological study in an ovine model of experimental acute myocardial infarction

To evaluate the prognostic significance of clinicopathological measurement in the diagnosis of acute myocardial infarction (MI) in sheep, acute MI was induced by ligation of left anterior descending coronary artery (LAD). For this purpose, twenty four healthy sheep were divided into the sham-operated or control group (group I, thoracotomy without MI) and the experimental group (group II, with M...

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Hematological Changes in an Ovine Model of Acute Myocardial Infarction

To diagnose acute myocardial infarction, selected cardiac markers as well as hematological and biochemical indices have been studied in human being, however, rare investigations were done on the values of hematologic analysis in an ovine model of myocardial infarction. To observe the change of the values in hematologic parameters in sheep, acute myocardial infarction was induced by ligation of ...

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clinicopathological study in an ovine model of experimental acute myocardial infarction

to evaluate the prognostic significance of clinicopathological measurement in the diagnosis of acute myocardial infarction (mi) in sheep, acute mi was induced by ligation of left anterior descending coronary artery (lad). for this purpose, twenty four healthy sheep were divided into the sham-operated or control group (group i, thoracotomy without mi) and the experimental group (group ii, with m...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2013

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2013/938047